Transmittance Measurements in Non-alternating Magnetic Field as Reliable Method for Determining of Heating Properties of Phosphate and Phosphonate Coated Fe3O4 Magnetic Nanoparticles

Different phosphates and phosphonates have shown excellent coating ability toward magnetic nanoparticles, improving their stability biocompatibility which enables biomedical application. The hyperthermia efficiency of (IDP IHP) (MDP HEDP) coated Fe3O4 nanoparticles (MNPs) were evaluated in an alternating field. For a deeper understanding hyperthermia, the behavior investigated MNPs non-alternating field was monitored by measuring transparency sample. To investigate theranostic potential Fe3O4-MNPs radiolabeled with radionuclide 177Lu. Phosphate high radiolabeling yield (> 99%) while phosphonate reached maximum 78%. Regardless lower both may be further purified reaching radiochemical purity more than 95%. In vitro stabile saline HSA obtained. heating as sine qua non for efficient vivo treatment satisfactory justifies research order to develop new agents.